Which UGT enzyme is listed among the metabolizing enzymes for brexpiprazole?

Which UGT enzyme is listed among the metabolizing enzymes for brexpiprazole?

• A. UGT1A4
• B. UGT2B7
• C. UGT1A9
• D. UGT2B15

Answer: (A)

Brexpiprazole undergoes glucuronidation, a phase II process where a sugar moiety is attached to the drug to make it more water-soluble for excretion. Among UGT enzymes, UGT1A4 is the primary contributor to brexpiprazole glucuronidation, forming the brexpiprazole glucuronide. The other UGTs listed are not shown to meaningfully participate in brexpiprazole’s glucuronidation, so they aren’t considered metabolizing enzymes for this drug in standard references. This is why UGT1A4 is the enzyme listed for brexpiprazole.

Brexpiprazole undergoes glucuronidation, a phase II process where a sugar moiety is attached to the drug to make it more water-soluble for excretion. Among UGT enzymes, UGT1A4 is the primary contributor to brexpiprazole glucuronidation, forming the brexpiprazole glucuronide. The other UGTs listed are not shown to meaningfully participate in brexpiprazole’s glucuronidation, so they aren’t considered metabolizing enzymes for this drug in standard references. This is why UGT1A4 is the enzyme listed for brexpiprazole.