Which receptor occupancies are reported for brexpiprazole in the data?

Which receptor occupancies are reported for brexpiprazole in the data?

• A. D2 occupancy only
• B. 5HT2A occupancy only
• C. Both D2 and 5HT2A
• D. Neither

Answer: (C)

Brexpiprazole engages two main receptor systems, so the data report occupancy at both D2 and 5HT2A receptors. It acts as a D2 receptor partial agonist and as a 5HT2A antagonist, so imaging studies measure how much of each receptor population is bound by the drug. This dual occupancy fits its clinical profile: sufficient D2 engagement to provide antipsychotic effects while 5HT2A occupancy helps modulate dopaminergic pathways and can reduce extrapyramidal symptoms. Therefore, the data show occupancies for both receptors, not just one or neither.

Brexpiprazole engages two main receptor systems, so the data report occupancy at both D2 and 5HT2A receptors. It acts as a D2 receptor partial agonist and as a 5HT2A antagonist, so imaging studies measure how much of each receptor population is bound by the drug. This dual occupancy fits its clinical profile: sufficient D2 engagement to provide antipsychotic effects while 5HT2A occupancy helps modulate dopaminergic pathways and can reduce extrapyramidal symptoms. Therefore, the data show occupancies for both receptors, not just one or neither.