Loxapine is the oral equivalent to which antipsychotic?

Loxapine is the oral equivalent to which antipsychotic?

• A. Chlorpromazine
• B. Haloperidol
• C. Olanzapine
• D. Risperidone

Answer: (A)

Loxapine is a phenothiazine antipsychotic, sharing chemical structure and pharmacology with chlorpromazine. Both are classic D2 dopamine receptor antagonists with similar effects on positive symptoms of schizophrenia and comparable sedative and anticholinergic side effects. Because of this close receptor profile and potency, loxapine is described as the oral equivalent to chlorpromazine. Haloperidol is a high-potency butyrophenone with a different risk and receptor pattern, often associated with more extrapyramidal symptoms. Olanzapine and risperidone are atypical antipsychotics with additional receptor actions (notably 5-HT2A antagonism) that give them different profiles from loxapine and chlorpromazine.

Loxapine is a phenothiazine antipsychotic, sharing chemical structure and pharmacology with chlorpromazine. Both are classic D2 dopamine receptor antagonists with similar effects on positive symptoms of schizophrenia and comparable sedative and anticholinergic side effects. Because of this close receptor profile and potency, loxapine is described as the oral equivalent to chlorpromazine. Haloperidol is a high-potency butyrophenone with a different risk and receptor pattern, often associated with more extrapyramidal symptoms. Olanzapine and risperidone are atypical antipsychotics with additional receptor actions (notably 5-HT2A antagonism) that give them different profiles from loxapine and chlorpromazine.