For Valbenazine, what is the recommended dose for acute dystonia administered via IM/IV?

For Valbenazine, what is the recommended dose for acute dystonia administered via IM/IV?

• A. 1-2 mg, may repeat in 30 minutes
• B. 5-10 mg, no repeat
• C. 0.5 mg, every 4 hours
• D. 20 mg, once

Answer: (A)

Valbenazine is a VMAT2 inhibitor used to treat tardive dyskinesia and is taken orally. It does not have an approved intramuscular or intravenous formulation, and its therapeutic effect for tardive dyskinesia develops over days, not in minutes. Acute dystonia requires rapid relief with a fast-acting, parenteral agent such as benztropine or diphenhydramine. Therefore there is no recommended IM/IV dose for valbenazine in acute dystonia. In practice, manage acute dystonia with quick-acting parenteral anticholinergics, and use valbenazine as the chronic oral treatment for tardive dyskinesia.

Valbenazine is a VMAT2 inhibitor used to treat tardive dyskinesia and is taken orally. It does not have an approved intramuscular or intravenous formulation, and its therapeutic effect for tardive dyskinesia develops over days, not in minutes. Acute dystonia requires rapid relief with a fast-acting, parenteral agent such as benztropine or diphenhydramine. Therefore there is no recommended IM/IV dose for valbenazine in acute dystonia. In practice, manage acute dystonia with quick-acting parenteral anticholinergics, and use valbenazine as the chronic oral treatment for tardive dyskinesia.