Cogentin is metabolized by which enzyme?

Cogentin is metabolized by which enzyme?

• A. CYP3A4
• B. CYP1A2
• C. CYP2D6
• D. CYP2C9

Answer: (C)

Cogentin is cleared mainly through the liver by the cytochrome P450 system, with CYP2D6 being the primary enzyme responsible for metabolizing benztropine. This means that a person’s CYP2D6 activity, which can vary genetically, directly affects how quickly benztropine is broken down. Inhibitors of CYP2D6 can slow its metabolism, increasing drug exposure and the potential for anticholinergic side effects. That’s why CYP2D6 is the best answer: it represents the main metabolic pathway for this drug.

Cogentin is cleared mainly through the liver by the cytochrome P450 system, with CYP2D6 being the primary enzyme responsible for metabolizing benztropine. This means that a person’s CYP2D6 activity, which can vary genetically, directly affects how quickly benztropine is broken down. Inhibitors of CYP2D6 can slow its metabolism, increasing drug exposure and the potential for anticholinergic side effects. That’s why CYP2D6 is the best answer: it represents the main metabolic pathway for this drug.